Phosphoramide mustard
WebJun 30, 2024 · Abstract. A series of novel artemisinin-piperazine-phosphoramide mustard (PPM) hybrids were designed and synthesized by incorporating phosphoramide mustard … WebJun 30, 2024 · A series of novel artemisinin-piperazine-phosphoramide mustard (PPM) hybrids were designed and synthesized by incorporating phosphoramide mustard (PM) into dihydroartemisinin (DHA) via an efficient, catalyst-free two-step sequential substitution.
Phosphoramide mustard
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WebApr 18, 2006 · In contrast to 4-hydroxycyclophosphamide, phosphoramide mustard cannot enter target cells, and therefore only the intracellularly formed phosphoramide mustard fraction is considered to be cytotoxic. WebPhosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage. For …
WebDec 19, 1995 · The local determinants for the formation of phosphoramide mustard-induced DNA interstrand cross-links were defined by using different pairs of synthetic … WebMar 2, 2024 · Ifosfamide belongs to the class of the oxazaphosphorine alkylating agents. It is an inactive compound in its parent form (prodrug). It is metabolized in the liver by CYP450 enzymes to active metabolites. These active metabolites (phosphoramide mustard derivatives and acrolein) bind to DNA and inhibit DNA synthesis. [13]
WebNov 9, 2012 · Cyclophosphamide is inactive until it undergoes hepatic transformation to form 4-hydroxycyclophosphamide, which then breaks down to form the ultimate alkylating agent, phosphoramide mustard. Sensitive and specific methods are now available for the measurement of cyclophosphamide, its metabolites and its stereoisomers in plasma and … WebAug 6, 2024 · Novel mustard functionalized sophoridine derivatives were synthesized and evaluated for their cytotoxicity against of a panel of various cancer cell lines. They were shown to be more sensitive to S180 and H22 tumor cells with IC50 values ranging from 1.01–3.65 μM, and distinctly were more cytotoxic to cancer cells than normal …
WebJun 1, 1995 · The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions. Journal of Medicinal Chemistry 1998 , 41 …
WebPhosphoramide mustard prevents cell division by forming cross-linkages in DNA both between and within DNA strands at guanine N-7 positions. This is irreversible and leads to … chimay whiskyWebPhosphoramide mustard, one of the principal toxic metabolites of cyclophosphamide, was synthesized and reported by Friedman and Seligman in 1954 …It was postulated that the … chimay visite brasserieWebSep 30, 2012 · It is very unstable and spontaneously decomposes into phosphoramide mustard by β-elimination of acrolein.[19,20,30,31] This conversion may be partly catalysed by albumin or other proteins.[32–34] Phosphoramide mustard is a bi-functional DNA alkylating agent and is considered to be the ultimate metabolite responsible for the … chimay white abvWebJun 1, 1995 · The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions. Journal of Medicinal Chemistry 1998 , 41 (4) , 515-529. chimay white cloneWebNov 1, 1993 · The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions. Journal of Medicinal Chemistry 1998, 41 … chimay white tripelWebJul 4, 2024 · National Center for Biotechnology Information chimay white capWebDescription: Phosphoramide mustard (PMC) is an alkylating agent and active metabolite of cyclophosphamide. It is formed from cyclophosphamide via the ring-opened tautomer of the cytochrome P450 (CYP) isoform-formed intermediate 4-hydroxycyclophosphamide. chimay white